Drew Wohl

  Back in late December/early January I noticed that I was having trouble getting onto my bike trainer.  It became more and more difficult to swing my left leg over the saddle. Since I am not the most flexible person, I figured it was general tightness.  So I made sure to focus on my stretching more after my biking and running sessions.  I thought I was gaining flexibility based on my range of motion.   But getting onto the bike became more difficult.  Then  started having difficulty doing other things.  I get an using my hands to lift my leg into bed or into the car.  Then dressing became more difficult. Then, on January 12, I fell down almost a full flight of stairs.  I thought it was my fault with my hands being full and thinking I went to grab something.  I wasn't sure, though I remember it was my left leg that went.  The fall was scary.  Time really does slow down.  I waited to hear the sound of my neck breaking....

 Spoke with my new Oncologist.  Really good things. First are the standard treatments available.  I ran through FOLFOX, FOLFORI and Lonsurf.  The last one left was Stivarga, but that is know for being nasty.  The one that my other doctor said may not be worth using because whatever extension of life would be really bad.  Of course I would probably try it if I had no other options.  I could try FOLFOX again for a few rounds before neuropathy.  But the best news is that FDA approved a new drug, Fruquintinib, two months ago.  It looks to be more effective than Stivarga, with less side effects. Second are the results being reported for CRC patients who have gotten immunotherapy. These results are new since immunotherapy has not been used much in CRC until recently.  80% of patients who had stable cancer from immunotherapy continued to have stable cancer two years after stopping the immunotherapy.  (It could last longer, but at this time...